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Generic Name:

teriflunomide, Oral tablet



Generic Name: teriflunomide, Oral tablet

All Brands

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Highlights for Aubagio

Oral tablet

Aubagio is used to decrease symptom flare-ups in people with multiple sclerosis.


You shouldn’t take Aubagio if you have severe liver problems.


You’ll need blood tests before starting Aubagio and each month for six months after you start taking it.


Common side effects of Aubagio include headache, hair thinning or loss, diarrhea, liver damage, and burning or prickling feeling on your skin.


Aubagio can stay in your blood for up to two years after you stop taking it.


FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

  • You should not take this drug if you have liver disease or increased markers of liver damage. This drug is processed by your liver and can cause liver damage. If you have liver disease already, this drug might make it worse.
  • Pregnant women should not take this drug. At certain levels in your blood, this drug may cause birth defects or fetal death. This drug may stay in your blood for up to two years after you stop taking it. So, you shouldn’t become pregnant for at least two years after you stop taking the drug.

Birth defect warning for men

If you’re a man taking this drug and your female partner plans to become pregnant, you should stop taking this drug and talk to your doctor about lowering your levels of the drug. Having a certain level of this drug in your blood may lead to birth defects in a child you have. You should try not to have a child until your doctor determines it‘s safe.

What is Aubagio?

This drug is a prescription drug. It is available as an oral tablet.

Why it's used

This drug is used to treat people with a type of multiple sclerosis in which symptoms temporarily go away and come back again.

How it works

This drug affects the body's immune system and helps reduce inflammation.

More Details

How it works

This drug affects the body's immune system and helps reduce inflammation. Multiple sclerosis causes inflammation of the protective covering of your nerves, which leads to the symptoms you experience. Decreasing inflammation with this drug can make your symptoms less likely to flare up.

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Aubagio Side Effects

Oral tablet

More Common Side Effects

The more common side effects that occur with Aubagio include:

  • headache

  • liver damage

  • hair thinning or loss

  • diarrhea

  • nausea

  • tingling, prickling, or burning of your skin

Mild side effects may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • liver damage. Symptoms include:

    • nausea
    • vomiting
    • stomach pain
    • loss of appetite
    • tiredness
    • yellowing of your skin or the whites of your eyes
    • dark urine
  • infection due to lowered immunity. Symptoms can include:

    • fever
    • tiredness
    • body aches
    • chills
    • nausea
    • vomiting
  • nerve damage. Symptoms can include:

    • numbness in your hands or feet
    • tingling in your hands or feet
    • burning sensation
  • serious skin reactions. Symptoms can include:

    • redness, peeling, or blistering
    • red or purple spots
    • small bumps
  • thrombocytopenia (low levels of platelets). Symptoms can include:

    • increased bleeding
    • frequent bruising
  • interstitial lung disease. Symptoms can include:

    • shortness of breath
    • tiredness
    • dry cough
  • pancreatitis. Symptoms can include:

    • nausea
    • vomiting
    • pain in the upper abdomen or back
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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Aubagio May Interact with Other Medications

Oral tablet

Aubagio may interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug


Aubagio is similar to the drug leflunomide. Both drugs can cause similar side effects. Taking them together can increase your risk of having more side effects and serious side effects such as liver damage, nerve damage, high blood pressure, and breathing problems.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
Pregnant women
Pregnant women

This drug is a category X pregnancy drug. Category X drugs should never be used during pregnancy because they’re known to harm your fetus if you’re pregnant.

Women who are breast-feeding
Women who are breast-feeding

It isn’t known if this drug passes through breast milk. If it does, the nursing child can be exposed to the drug, which can result in potentially dangerous side effects in the child. 

To be on the safe side, if you’re breastfeeding, talk to your doctor about whether you should stop the drug or stop breastfeeding.

For seniors
For seniors

This drug hasn’t been studied in people over the age of 65 years.

allergy warning

Aubagio can cause a severe allergic reaction. Avoid this drug if you’ve had an allergic reaction to teriflunomide, leflunomide, or any other ingredients in Aubagio. Symptoms of a reaction can include:

  • trouble breathing
  • swelling of your throat or tongue
  • serious skin reactions, including swelling

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take Aubagio (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Multiple sclerosis (MS)

Brand: Aubagio

Form: Oral tablet
Strengths: 7mg and 14 mg
Adult dosage (ages 18–64 years)

The dosage for people aged 18 years or older depends on the person. The dosage is either 7 mg or 14 mg per day. Your doctor will determine the most appropriate dose for your condition. The dose may be higher or lower depending on the severity of your symptoms.

Child dosage (ages 0–17 years)

This medicine has not been studied in children and should not be safe and effective in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with risks if you don’t take it as prescribed by your doctor.

If you don't take it at all

Multiple sclerosis can damage your nervous system even when you’re not experiencing symptoms. If you don’t take this drug, the damage to your nervous system can get worse.

If you skip or miss doses

If you miss doses or don’t take it at the time you’re supposed to, you may have more flare-ups of your symptoms.

If you take too much

Call your doctor or go to the nearest emergency room immediately if you take too much of this drug. Taking too much increases your risk of dangerous side effects, such as liver damage. Your doctor may be able to use other medications to lower the levels of this drug in your blood, which might prevent dangerous side effects.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If you remember just a few hours before the time for your next dose, only take one dose.

Never try to catch up by taking two tablets at once. This could result in toxic side effects. Contact your pharmacist or doctor with any questions.

How can I tell if the drug is working?

If this drug is working, you may notice a decrease in multiple sclerosis flare-ups.

This drug is a long-term drug treatment.

Important considerations for taking this drug

Store this drug between 68°F (20ºC) to 77°F (25ºC)

Store it away from high temperature.

Keep drugs away from moisture and areas where they could get wet, such as bathrooms.


When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription-labeled bottle when traveling with your medication.

Clinical Monitoring

Liver function: Your doctor will check your liver function with blood tests before starting this drug and once monthly for six months after starting. If your liver tests show signs of liver injury, your doctor may tell you to stop treatment with this drug.


Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are several drugs that can treat multiple sclerosis. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 14, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.